Ethyl 4-chloroacetoacetate → HCID 178472214, compound

HRID 1649410Notes

Reaction equation

HRID 1649410 reaction equation
[CH3:1][C:2]1[O:6][N:5]=[C:4](C=O)[CH:3]=1.[CH2:9]([O:11][C:12](=[O:18])[CH2:13][C:14]([CH2:16][Cl:17])=[O:15])[CH3:10]>>[CH2:9]([O:11][C:12](=[O:18])[C:13](=[C:4]1[CH:3]=[C:2]([CH3:1])[O:6][NH:5]1)[C:14](=[O:15])[CH2:16][Cl:17])[CH3:10]

Participants

3

Reactant 2

HCID 69484Ethyl 4-chloroacetoacetateHCID 27952225-Methyl-1,2-oxazole-3-carbaldehyde

Product 1

HCID 178472214HCID 178472214, compound

Procedure

79.5 g of 5-methylisoxazole-3-aldehyde were reacted with 4-chloroacetoacetic acid ethyl ester as described in Example 24. A crude product, which was chromatographically pure, was obtained. This isomer ratio was 2:1.

Workup

  1. customwas obtained

Sources & evidence

ORD record
ord-d009df4d831541ce87b16fd791a38711
Source dataset
uspto-grants-1983_11
Patent number
US04416880

Reaction notes

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