Hydrogen Bromide → 8-(4-methyl-1-piperazinyl)-9-fluoro-5-methyl-6,7-dihydro-1-oxo-1H,5H-benzo[ij]quinolizine-2-carboxylic acid hydrobromide monohydrate

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Reaction Steps

8-(4-Methyl-1-piperazinyl)-9-fluoro-5-methyl-6,7-dihydro-1-oxo-1H,5H-benzo[ij]quinolizine-2-carboxylic acid was added to 48% hydrobromic acid and the solvent was removed by distillation under reduced pressure. Recrystallization of the residue from isopropanol-water (2:1 by volume) gave 8-(4-methyl-1-piperazinyl)-9-fluoro-5-methyl-6,7-dihydro-1-oxo-1H,5H-benzo[ij]quinolizine-2-carboxylic acid hydrobromide monohydrate as white rhombic crystals having a melting point of 298° to 299° C. (decomposed).

Provenance & Evidence