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HRID1649451

反应详情

EQUATION

反应方程式

HRID 1649451 的结构方程式

REACTANTS

反应物

2
反应SMILES：Br
HCID260

Hydrogen Bromide

BrH

反应SMILES：CC1CCc2c(N3CCN(C)CC3)c(F)cc3c(=O)c(C(=O)O)cn1c23
HCID71235

9-Fluoro-5-methyl-8-(4-methylpiperazin-1-yl)-1-oxo-6,7-dihydro-1H,5H-pyrido[3,2,1-ij]quinoline-2-carboxylic acid

C19H22FN3O3

PRODUCTS

产物

1
反应SMILES：Br.CC1CCc2c(N3CCN(C)CC3)c(F)cc3c(=O)c(C(=O)O)cn1c23.O
HCID70527948

未命名化合物

PROCEDURE

实验过程

8-(4-Methyl-1-piperazinyl)-9-fluoro-5-methyl-6,7-dihydro-1-oxo-1H,5H-benzo[ij]quinolizine-2-carboxylic acid was added to 48% hydrobromic acid and the solvent was removed by distillation under reduced pressure. Recrystallization of the residue from isopropanol-water (2:1 by volume) gave 8-(4-methyl-1-piperazinyl)-9-fluoro-5-methyl-6,7-dihydro-1-oxo-1H,5H-benzo[ij]quinolizine-2-carboxylic acid hydrobromide monohydrate as white rhombic crystals having a melting point of 298° to 299° C. (decomposed).

WORKUP

后处理

  1. customthe solvent was removed by distillation under reduced pressure
  2. customRecrystallization of the residue from isopropanol-water (2:1 by volume)