反应详情

A solution of 72 g of N-methyl-2-nitrobenzenesulfonamide, 35 g of tetrafluoroethylene and 4 g of powdered potassium hydroxide in 150 ml of dimethylformamide was heated at 85° for 3 hours in a pressure vessel. The reaction mixture was cooled to 25° and poured into 800 ml of water. A heavy oil was separated and the aqueous layer extracted with 150 ml of 1-chlorobutane. The heavy oil, the 1-chlorobutane extract and an additional 300 ml of 1-chlorobutane were combined and washed three times with water. The organic solution was dried over magnesium sulfate and concentrated in-vacuo to yield 85.1 g of N-methyl-N-(1,1,2,2-tetrafluoroethyl)-2-nitrobenzenesulfonamide as a viscous orange oil.

1. temperatureThe reaction mixture was cooled to 25°
2. customA heavy oil was separated
3. extractionthe aqueous layer extracted with 150 ml of 1-chlorobutane
4. extractionThe heavy oil, the 1-chlorobutane extract
5. washwashed three times with water
6. dry with materialThe organic solution was dried over magnesium sulfate
7. concentrationconcentrated in-vacuo