Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | HCID 20479100 | HCID 20479100 | — |
| Product | HCID 86020215 | HCID 86020215 | 80% |
Reaction Steps
A solution of ethyl 2,4-difluoro-3-benzylamino-butanoate prepared as in Step B (1.240 g, 4.8 mM) in 1 N hydrochloric acid (30 ml) is heated at 100° C. for 4 hours. The solvent is removed in vacuo. The crude product is taken off several times in isopropanol and the alcohol evaporated evaporated in vacuo. 2,4-Difluoro 3-benzylamino-butanoic acid, hydrochloride is obtained as a white solid, recrystallized from ethanol/ether: 1.010 g (yield about 80%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04418077 |
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| Source dataset | uspto-grants-1983_11 |
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| ORD ID | ord-748002df8ed64a21874da1aee6036eed |
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| Source note | uspto-grants-1983_11 |
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