Hydrochloric Acid → HCID 86020215, compound

HRID 1649553Notes

Reaction equation

HRID 1649553 reaction equation
[F:1][CH:2]([CH:8]([NH:11][CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[CH2:9][F:10])[C:3]([O:5]CC)=[O:4].[ClH:19]>>[ClH:19].[F:1][CH:2]([CH:8]([NH:11][CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[CH2:9][F:10])[C:3]([OH:5])=[O:4]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 20479100HCID 20479100, compound

Product 1

HCID 86020215HCID 86020215, compoundYield 80%

Conditions

Temperature
100 °C

Procedure

A solution of ethyl 2,4-difluoro-3-benzylamino-butanoate prepared as in Step B (1.240 g, 4.8 mM) in 1 N hydrochloric acid (30 ml) is heated at 100° C. for 4 hours. The solvent is removed in vacuo. The crude product is taken off several times in isopropanol and the alcohol evaporated evaporated in vacuo. 2,4-Difluoro 3-benzylamino-butanoic acid, hydrochloride is obtained as a white solid, recrystallized from ethanol/ether: 1.010 g (yield about 80%).

Workup

  1. customThe solvent is removed in vacuo
  2. customthe alcohol evaporated
  3. customevaporated in vacuo

Sources & evidence

ORD record
ord-748002df8ed64a21874da1aee6036eed
Source dataset
uspto-grants-1983_11
Patent number
US04418077

Reaction notes

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