Cyclopropylamine → HCID 14013803, compound

HRID 1649669Notes

Reaction equation

HRID 1649669 reaction equation
[F:1][C:2]([F:24])([F:23])[C:3]1[C:8]([C:9]([O:11][CH2:12][CH3:13])=[O:10])=[C:7](Cl)[C:6]([C:15]([O:17][CH3:18])=[O:16])=[C:5]([C:19]([F:22])([F:21])[F:20])[N:4]=1.[CH:25]1([NH2:28])[CH2:27][CH2:26]1>CN(C=O)C>[CH:25]1([NH:28][C:7]2[C:6]([C:15]([O:17][CH3:18])=[O:16])=[C:5]([C:19]([F:20])([F:21])[F:22])[N:4]=[C:3]([C:2]([F:24])([F:23])[F:1])[C:8]=2[C:9]([O:11][CH2:12][CH3:13])=[O:10])[CH2:27][CH2:26]1

Participants

4

Reactant 2

HCID 69828CyclopropylamineHCID 14013761HCID 14013761, compound

Product 1

HCID 14013803HCID 14013803, compoundYield 95.1%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

This compound was prepared as described in Example 37: 5.0 g (0.013 mol) of product of Example 27, 1.83 ml (0.026 mol) of cyclopropylamine in 30 ml of DMF were reacted at room temperature affording 4.95 g of dark oil which was purified by HPLC using 5% ethyl acetate/cyclohexane as eluting solvent to give 3.87 g (74.4%) of product as a yellow oil, nD25 1.4708.

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-afb8cd2d71c9420fb00e5398fa181613
Source dataset
uspto-grants-1990_05
Patent number
US04921530

Reaction notes

Loading…