Methylamine → HCID 14013943, compound

HRID 1649705Notes

Reaction equation

HRID 1649705 reaction equation
[F:1][C:2]([F:28])([F:27])[C:3]1[N:8]=[C:7]([CH:9]([F:11])[F:10])[C:6]([C:12]([O:14][CH3:15])=[O:13])=[C:5]([NH:16][CH:17]([CH3:19])[CH3:18])[C:4]=1[C:20]([N:22]1[CH:26]=CC=N1)=[O:21].CN>CCOCC>[F:11][CH:9]([F:10])[C:7]1[N:8]=[C:3]([C:2]([F:28])([F:1])[F:27])[C:4]([C:20]([NH:22][CH3:26])=[O:21])=[C:5]([NH:16][CH:17]([CH3:19])[CH3:18])[C:6]=1[C:12]([O:14][CH3:15])=[O:13]

Participants

4

Reactant 2

HCID 6329MethylamineHCID 14013955HCID 14013955, compound

Product 1

HCID 14013943HCID 14013943, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Conditions

Temperature
30 °C

Procedure

To a mixture of 10 g (0.03 mol) of the acid chloride prepared in Example 200 in 500 mL of Et2O was added an excess of anhydrous methyl amine and the mixture was stirred at 30° C. for 4 hours. The reaction mixture was cooled to 25° C., and concentrated in vacuo to a white powder which was extracted with CHCl3 using a soxhlet apparatus. The CHCl3 was concentrated in vacuo to 8.8 g (88%) of product as a white solid: mp 128°-130° C.

Workup

  1. temperatureThe reaction mixture was cooled to 25° C.
  2. concentrationconcentrated in vacuo to a white powder which
  3. extractionwas extracted with CHCl3 using a soxhlet apparatus
  4. concentrationThe CHCl3 was concentrated in vacuo to 8.8 g (88%) of product as a white solid

Sources & evidence

ORD record
ord-d60a17d110cc45d1a2d6b3dc3bef050f
Source dataset
uspto-grants-1990_05
Patent number
US04921530

Reaction notes

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