3-(4-Fluorobenzoyl)butanoic acid → 3-[4-[4-(3-phthalimidopropyl)-1H-imidazol-1-yl]benzoyl]-butyric acid

HRID 1649717Notes

Reaction equation

HRID 1649717 reaction equation
[C:1]1(=[O:19])[N:5]([CH2:6][CH2:7][CH2:8][C:9]2[N:10]=[CH:11][NH:12][CH:13]=2)[C:4](=[O:14])[C:3]2=[CH:15][CH:16]=[CH:17][CH:18]=[C:2]12.F[C:21]1[CH:34]=[CH:33][C:24]([C:25]([CH:27]([CH3:32])[CH2:28][C:29]([OH:31])=[O:30])=[O:26])=[CH:23][CH:22]=1>>[C:4]1(=[O:14])[N:5]([CH2:6][CH2:7][CH2:8][C:9]2[N:10]=[CH:11][N:12]([C:21]3[CH:34]=[CH:33][C:24]([C:25]([CH:27]([CH3:32])[CH2:28][C:29]([OH:31])=[O:30])=[O:26])=[CH:23][CH:22]=3)[CH:13]=2)[C:1](=[O:19])[C:2]2=[CH:18][CH:17]=[CH:16][CH:15]=[C:3]12

Participants

3

Reactant 2

HCID 124495243-(4-Fluorobenzoyl)butanoic acidHCID 1785149894-(3-Phthalimidopropyl)-imidazole

Product 1

HCID 198545433-[4-[4-(3-phthalimidopropyl)-1H-imidazol-1-yl]benzoyl]-butyric acid

Procedure

Prepared by a method analogous to that of Example (a) from 2.6 g (10.2 mmol) of 4-(3-phthalimidopropyl)-imidazole and 2.2 g (10.5 mmol) of 3-(4-fluorobenzoyl)-butyric acid. 3.4 g (75%) of a brownish, viscous oil is obtained which is used without further purification for the next stage.

Workup

  1. custom3.4 g (75%) of a brownish, viscous oil is obtained which
  2. customis used without further purification for the next stage

Sources & evidence

ORD record
ord-1f5e558becb94183bc1b6135bbac3435
Source dataset
uspto-grants-1990_05
Patent number
US04921856

Reaction notes

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