Hydrochloric Acid → 6-[3-(Imidazol-1-yl)propyl]-3,4-dihydrocarbostyril hydrochloride

HRID 1649748Notes

Reaction equation

HRID 1649748 reaction equation
[ClH:1].[N:2]1([CH2:7][CH2:8][CH2:9][C:10]2[CH:11]=[C:12]3[C:17](=[CH:18][CH:19]=2)[NH:16][C:15](=[O:20])[CH2:14][CH2:13]3)[CH:6]=[CH:5][N:4]=[CH:3]1.C(OCC)C>CO>[ClH:1].[N:2]1([CH2:7][CH2:8][CH2:9][C:10]2[CH:11]=[C:12]3[C:17](=[CH:18][CH:19]=2)[NH:16][C:15](=[O:20])[CH2:14][CH2:13]3)[CH:6]=[CH:5][N:4]=[CH:3]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 143732856-[3-(Imidazol-1-yl)propyl]-3,4-dihydrocarbostyril

Product 1

HCID 198547386-[3-(Imidazol-1-yl)propyl]-3,4-dihydrocarbostyril hydrochloride

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

A twofold stoichiometric excess of a 3% solution of hydrogen chloride in methanol is added to a solution of 1.0 g of 6-[3-(imidazol-1-yl)propyl]-3,4-dihydrocarbostyril in 50 ml of methanol at 25° C. Diethyl ether is then added to the stirred solution until precipitation is complete. The precipitate is filtered off, washed with ether and recrystallized from a mixture of methanol and ethyl acetate to give 6-[3-(imidazol-1-yl)propyl]-3,4-dihydrocarbostyril hydrochloride.

Workup

  1. filtrationThe precipitate is filtered off
  2. washwashed with ether
  3. customrecrystallized from a mixture of methanol and ethyl acetate

Sources & evidence

ORD record
ord-27ff266c2bf64e04b27cae9dc0d015e9
Source dataset
uspto-grants-1990_05
Patent number
US04921862

Reaction notes

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