Hydrochloric Acid → HCID 19854389, compound

HRID 1649766Notes

Reaction equation

HRID 1649766 reaction equation
[ClH:1].C(OC([NH:9][CH2:10][CH2:11][S:12][C:13]1[CH:14]=[CH:15][C:16]2[N:17]([CH:19]=[CH:20][N:21]=2)[N:18]=1)=O)(C)(C)C>>[ClH:1].[ClH:1].[NH2:9][CH2:10][CH2:11][S:12][C:13]1[CH:14]=[CH:15][C:16]2[N:17]([CH:19]=[CH:20][N:21]=2)[N:18]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 14456838HCID 14456838, compound

Product 1

HCID 19854389HCID 19854389, compound

Procedure

To 100 ml of 3N-hydrochloric acid is added 5.89 g of 6-(2-tert-butoxycarbonylaminoethylthio)imidazo[1,2-b]pyridazine and the mixture is refluxed with stirring for 20 minutes. The solvent is distilled off under reduced pressure and the residue is diluted with 50 ml of toluene and concentrated again under reduced pressure. To the residue is added ether and the resulting powers are collected by filtration and washed with ether, ethanol and ether in the order mentioned to give 5.26 g of 6-(2-aminoethylthio)imidazo[ 1,2-b]pyridazine dihydrochloride as colorless powders.

Workup

  1. temperaturethe mixture is refluxed
  2. distillationThe solvent is distilled off under reduced pressure
  3. additionthe residue is diluted with 50 ml of toluene
  4. concentrationconcentrated again under reduced pressure
  5. additionTo the residue is added ether
  6. filtrationthe resulting powers are collected by filtration
  7. washwashed with ether, ethanol and ether in the order

Sources & evidence

ORD record
ord-470ae79806e74e7380760593fe5586ee
Source dataset
uspto-grants-1990_05
Patent number
US04921851

Reaction notes

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