Potassium Iodide → HCID 14280680, compound

HRID 1649774Notes

Reaction equation

HRID 1649774 reaction equation
[Cl:1][CH2:2][CH2:3][C:4]1[CH:13]=[CH:12][C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=1.[F:14][C:15]1[CH:27]=[CH:26][C:18]([CH2:19][CH:20]2[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]2)=[CH:17][CH:16]=1.[I-].[K+].C(=O)([O-])O.[Na+]>C(O)CCC>[ClH:1].[F:14][C:15]1[CH:16]=[CH:17][C:18]([CH2:19][CH:20]2[CH2:21][CH2:22][N:23]([CH2:2][CH2:3][C:4]3[CH:13]=[CH:12][C:11]4[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=4)[CH:5]=3)[CH2:24][CH2:25]2)=[CH:26][CH:27]=1

Participants

6

Reactant 4

HCID 4875Potassium IodideHCID 516892Sodium BicarbonateHCID 36998414-(4-Fluoro-benzyl)-piperidineHCID 12698954HCID 12698954, compound

Product 1

HCID 14280680HCID 14280680, compound

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

1.05 g of 1-chloro-2-(2-naphthyl)ethane, 1.09 g of 4-(p-fluorobenzyl)piperidine, 0.2 g of potassium iodide and 1.4 g of sodium hydrogencarbonate were refluxed in n-butanol solvent for 5 h. Then, the solvent was filtered out and 100 ml of chloroform was added to the residue. The mixture was washed with water and dried over magnesium sulfate. The oily product thus obtained was purified according to silica gel column chromatography and converted into its hydrochloride by an ordinary method.

Workup

  1. filtrationThen, the solvent was filtered out and 100 ml of chloroform
  2. additionwas added to the residue
  3. washThe mixture was washed with water
  4. dry with materialdried over magnesium sulfate
  5. customThe oily product thus obtained
  6. customwas purified

Sources & evidence

ORD record
ord-2125b56587654f56aba5c0186169006c
Source dataset
uspto-grants-1990_05
Patent number
US04921863

Reaction notes

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