Diethylamine → 2-Bromo-N,N-diethyl-4-pyridinecarboxamide

Participants

Reaction Steps

Ethyl chloroformate (1.07 g) was added dropwise to a solution of 2-bromo-4-pyridinecarboxylic acid (2 g) and triethylamine (1 g) at 0°. The mixture was stirred at room temperature for 1 h, diethylamine (3 ml) was added dropwise and the resulting suspension was stirred vigorously for 2 h. The precipitate was collected by filtration and washed with water (20 ml) to give the title compound as a white solid (1.55 g), m.p. 200°-203°.

Provenance & Evidence