Diethylamine → HCID 19854792, compound

HRID 1649783Notes

Reaction equation

HRID 1649783 reaction equation
ClC(OCC)=O.[Br:7][C:8]1[CH:13]=[C:12]([C:14]([OH:16])=O)[CH:11]=[CH:10][N:9]=1.[CH2:17]([NH:19][CH2:20][CH3:21])[CH3:18]>C(N(CC)CC)C>[Br:7][C:8]1[CH:13]=[C:12]([C:14]([N:19]([CH2:20][CH3:21])[CH2:17][CH3:18])=[O:16])[CH:11]=[CH:10][N:9]=1

Participants

5

Reactant 3

HCID 8021DiethylamineHCID 10928Ethyl chloroformateHCID 2227012-Bromoisonicotinic acid

Product 1

HCID 19854792HCID 19854792, compound

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

Ethyl chloroformate (1.07 g) was added dropwise to a solution of 2-bromo-4-pyridinecarboxylic acid (2 g) and triethylamine (1 g) at 0°. The mixture was stirred at room temperature for 1 h, diethylamine (3 ml) was added dropwise and the resulting suspension was stirred vigorously for 2 h. The precipitate was collected by filtration and washed with water (20 ml) to give the title compound as a white solid (1.55 g), m.p. 200°-203°.

Workup

  1. stirringthe resulting suspension was stirred vigorously for 2 h
  2. filtrationThe precipitate was collected by filtration
  3. washwashed with water (20 ml)

Sources & evidence

ORD record
ord-14c54cb78bf2423eb1805cd825acbc48
Source dataset
uspto-grants-1990_05
Patent number
US04921867

Reaction notes

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