反应详情

p-aminophenol 33.36 g (0.3 mole) and 12 g NaOH were dissolved in 120 ml water and cooled to ice salt bath temperature. To the stirring solution, 24 ml ethylchloroformate were slowly added. A white precipitate was found. One gram sodium dithionite was added and mixed. The solid was filtered by suction and washed with cold water (50 ml). Recrystallization from hot water gave a crystalline powder, 48.3 g (89%), MP 120-123°.

1. temperaturecooled to ice salt bath temperature
2. additionmixed
3. filtrationThe solid was filtered by suction
4. washwashed with cold water (50 ml)
5. customRecrystallization from hot water
6. customgave a crystalline powder, 48.3 g (89%), MP 120-123°