Hydrazine hydrate (1:1) → HCID 13674791, compound

HRID 1649975Notes

Reaction equation

HRID 1649975 reaction equation
O.NN.C1(=O)[N:8]([CH2:9][CH:10]([N:12]([CH3:21])[C:13]2[C:18]([CH3:19])=[CH:17][CH:16]=[CH:15][C:14]=2[CH3:20])[CH3:11])C(=O)C2=CC=CC=C12>C(O)C>[NH2:8][CH2:9][CH:10]([N:12]([CH3:21])[C:13]1[C:18]([CH3:19])=[CH:17][CH:16]=[CH:15][C:14]=1[CH3:20])[CH3:11]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 13674788HCID 13674788, compound

Product 1

HCID 13674791HCID 13674791, compoundYield 74.5%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2.5 ml of a 90% hydrazine hydrate are added to a solution of 3.0 g (9.3 mmoles) of 1-phthalimido-2-[N-methyl-N-(2,6-dimethylphenyl)-amino]-propane in 30 ml of ethanol, and the mixture is boiled for one hour. Next day the mixture is processed as described in Example 11, and the crude product is distilled under reduced pressure. 1.33 g (74.5%) of 1-amino-2-[N-methyl-N-(2,6-dimethylphenyl)-amino]-propane are obtained; b.p.: 97°-99° C./53.3 Pa. The monohydrochloride of the product, prepared as described in Example 1, melts at 158°-160° C.

Workup

  1. distillationthe crude product is distilled under reduced pressure

Sources & evidence

ORD record
ord-87057103b88e4911b8fc036e3a9fb925
Source dataset
uspto-grants-1990_05
Patent number
US04922021

Reaction notes

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