HCID 13674870, compound → HCID 13674809, compound

HRID 1649996Notes

Reaction equation

HRID 1649996 reaction equation
[CH2:1]([N:3]([CH2:7][CH:8]([NH:10][C:11]1[C:16]([CH3:17])=[CH:15][CH:14]=[CH:13][C:12]=1[CH3:18])[CH3:9])[C:4](=O)[CH3:5])[CH3:2].[H-].[Al+3].[Li+].[H-].[H-].[H-]>C(OCC)C>[CH2:4]([N:3]([CH2:1][CH3:2])[CH2:7][CH:8]([NH:10][C:11]1[C:12]([CH3:18])=[CH:13][CH:14]=[CH:15][C:16]=1[CH3:17])[CH3:9])[CH3:5]

Participants

4

Reactant 2

HCID 13674870HCID 13674870, compoundHCID 21226445Aluminium lithium hydride

Product 1

HCID 13674809HCID 13674809, compoundYield 74.7%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent2×

Procedure

A solution of 0.2 g (0.8 mmoles) of 1-(N-ethyl-acetamido)-2(2,6-dimethylphenyl-amino)-propane, prepared as described in Example 31, in 5 ml of dry diethyl ether is added dropwise, within 10 minutes, to a vigorously stirred suspension of 0.2 g of lithium aluminium hydride in 10 ml of dry diethyl ether at room temperature. The resulting mixture is stirred at room temperature for 3 hours and then processed as described in Example 29. 0.14 g (74%) of 1-diethylamino-2-(2,6-dimethylphenyl-amino)-propane are obtained.

Sources & evidence

ORD record
ord-813e676c66a54e6cab1a8aba2eda6fb2
Source dataset
uspto-grants-1990_05
Patent number
US04922021

Reaction notes

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