HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sulfuric Acid → (17alpha)-17-Hydroxy-3-oxoandrosta-4,9(11)-diene-17-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | 17-Cyano-9,17-dihydroxyandrost-4-ene-3-one | HCID 3082778 | — |
| Solvent | Water | HCID 962 | — |
| Product | (17alpha)-17-Hydroxy-3-oxoandrosta-4,9(11)-diene-17-carbonitrile | HCID 10859900 | — |
Reaction Steps
17β-Cyano-9α,17α-dihydroxyandrost-4-en-3-one (I, EXAMPLE 85, 313 mg) is added to sulfuric acid (57%, 5 ml) at 2° and is stirred at 2°-5° for several hr and then overnight at 22°; solids formed. Water (10 ml) is added at 10°, the mixture stirred for 15 min, the solids collected and air dried to give the title compound, NMR (CDCl3 /DMSO-d6 ; 5/1) 5.7, 5.6, 1.4 and 0.9 δ.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04921638 |
| Source dataset | uspto-grants-1990_05 |
| ORD ID | ord-8a7407084025441487b5cfe4085f2b7c |
| Source note | uspto-grants-1990_05 |