Sulfuric Acid → HCID 14281515, compound

HRID 1650095Notes

Reaction equation

HRID 1650095 reaction equation
[CH:1]([C:4]([CH3:14])([N:7]1[C:11](=[O:12])[CH:10]=[CH:9][C:8]1=[O:13])[C:5]#[N:6])([CH3:3])[CH3:2].S(=O)(=O)(O)[OH:16].[Cl-].[Na+].C(OCC)(=O)C>C(Cl)Cl>[CH:1]([C:4]([CH3:14])([N:7]1[C:11](=[O:12])[CH:10]=[CH:9][C:8]1=[O:13])[C:5]([NH2:6])=[O:16])([CH3:3])[CH3:2]

Participants

6

Reactant 4

HCID 1118Sulfuric AcidHCID 5234Sodium ChlorideHCID 8857Ethyl AcetateHCID 13730721HCID 13730721, compound

Product 1

HCID 14281515HCID 14281515, compoundYield 72%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of α-isopropyl-α-methyl-2,5-dioxo-3-pyrroline-1-acetonitrile (2.0 g, 0.104 mol) in methylene chloride (30 ml) is added in a fine stream to concentrated sulfuric acid at room temperature. After stirring overnight at room temperature for 16 hours the mixture is poured onto ice, containing sodium chloride and ethyl acetate. The organic layer is washed with aqueous sodium bicarbonate, brine and dried. Evaporation after washing with ether-pentane gives a solid (72%), mp 138.5°-140° C. Anal. calcd. for C10H14N2O3 : C, 57.13; H, 6.71; N, 13.33. Found: C, 56.89; H, 6.64; N, 13.16.

Workup

  1. additionis poured onto ice
  2. washThe organic layer is washed with aqueous sodium bicarbonate, brine
  3. customdried
  4. customEvaporation
  5. washafter washing with ether-pentane

Sources & evidence

ORD record
ord-5121654682c645f49984ff692f5fee41
Source dataset
uspto-grants-1990_05
Patent number
US04923504

Reaction notes

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