Ammonia → HCID 6918136, compound

HRID 1650130Notes

Reaction equation

HRID 1650130 reaction equation
Cl.[NH2:2][C:3]1[C:8]([NH:9][C:10]([O:12][CH2:13][CH2:14]Br)=[O:11])=[CH:7][CH:6]=[C:5]([NH:16][CH2:17][C:18]2[CH:23]=[CH:22][C:21]([F:24])=[CH:20][CH:19]=2)[N:4]=1.N>CO>[NH2:2][C:3]1[C:8]([N:9]2[CH2:14][CH2:13][O:12][C:10]2=[O:11])=[CH:7][CH:6]=[C:5]([NH:16][CH2:17][C:18]2[CH:23]=[CH:22][C:21]([F:24])=[CH:20][CH:19]=2)[N:4]=1

Participants

4

Reactant 2

HCID 222Ammonia2×HCID 23053678HCID 23053678, compound

Product 1

HCID 6918136HCID 6918136, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A suspension of 50 g (0.12 Mol) of 2-amino-3-[(2-bromethoxy)-carbonylamino]-6-(4-fluoro-benzylamino)-pyridine hydrochloride in 200 ml of methanol is added to 250 ml of 10% ethanolic ammonia and the mixture is stirred for a total of 24 hours at room temperature under argon (with a further 100 ml of 10% ethanolic ammonia being added after 12 hours). The resultant crystalline compound is filtered under suction and dried in a vacuum at room temperature.

Workup

  1. additionadded after 12 hours)
  2. filtrationThe resultant crystalline compound is filtered under suction
  3. customdried in a vacuum at room temperature

Sources & evidence

ORD record
ord-b4c7493bda4b40aead1e224e2cfa0ac3
Source dataset
uspto-grants-1990_05
Patent number
US04923858

Reaction notes

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