Ammonia → HCID 6918136, compound

Participants

Reaction Steps

A suspension of 50 g (0.12 Mol) of 2-amino-3-[(2-bromethoxy)-carbonylamino]-6-(4-fluoro-benzylamino)-pyridine hydrochloride in 200 ml of methanol is added to 250 ml of 10% ethanolic ammonia and the mixture is stirred for a total of 24 hours at room temperature under argon (with a further 100 ml of 10% ethanolic ammonia being added after 12 hours). The resultant crystalline compound is filtered under suction and dried in a vacuum at room temperature.

Provenance & Evidence