Ethanol → HCID 14608785, compound

HRID 1650147Notes

Reaction equation

HRID 1650147 reaction equation
C([C:3]1[N:4]2[C:9]([CH:10]=[CH:11][CH:12]=1)=[CH:8][C:7](=[O:13])[C:6]1[CH:14]=[C:15]([F:25])[C:16]([N:18]3[CH2:23][CH2:22][N:21]([CH3:24])[CH2:20][CH2:19]3)=[CH:17][C:5]2=1)C.[OH-:26].[Na+].[CH2:28]([OH:30])C>C(O)(=O)C>[F:25][C:15]1[C:16]([N:18]2[CH2:19][CH2:20][N:21]([CH3:24])[CH2:22][CH2:23]2)=[CH:17][C:5]2[N:4]3[C:9]([CH:10]=[CH:11][CH:12]=[CH:3]3)=[C:8]([C:28]([OH:30])=[O:26])[C:7](=[O:13])[C:6]=2[CH:14]=1

Participants

5

Reactant 3

HCID 702EthanolHCID 14798Sodium HydroxideHCID 70356753HCID 70356753, compound

Product 1

HCID 14608785HCID 14608785, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A mixture of 0.38 g of ethyl 8-fluoro-9-(4-methyl-1-piperazinyl)-6-oxo-6H-benzo[c]quinolizine, 25 ml of 0.1N sodium hydroxide and 5 ml of ethyl alcohol was refluxed for 18 hours. The mixture was cooled to room temperature and the pH adjusted to 6 with acetic acid. Most of the volatiles were removed under vacuum to give 0.31 g of water washed and dried desired product, mp 264°-266° C.

Workup

  1. temperaturewas refluxed for 18 hours
  2. customMost of the volatiles were removed under vacuum
  3. customto give 0.31 g of water
  4. washwashed
  5. dry with materialdried desired product, mp 264°-266° C.

Sources & evidence

ORD record
ord-3771af42d0a84fa08b467b080af58d53
Source dataset
uspto-grants-1990_05
Patent number
US04923868

Reaction notes

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