Dichloromethane → 5-Methyl-2-[4-(piperidin-4-yloxy)phenyl]-2H-pyrazole-3-carboxylic acid cyclohexylamide

HRID 165022Notes

Reaction equation

HRID 165022 reaction equation
[C:1]([O:2][C:3](=[O:4])[N:8]1[CH2:9][CH2:10][CH:11]([O:14][c:15]2[cH:16][cH:17][c:18](-[n:21]3[n:22][c:23]([CH3:35])[cH:24][c:25]3[C:26]([NH:27][CH:28]3[CH2:29][CH2:30][CH2:31][CH2:32][CH2:33]3)=[O:34])[cH:19][cH:20]2)[CH2:12][CH2:13]1)([CH3:5])([CH3:6])[CH3:7].[CH2:43]([Cl:44])[Cl:45].[OH:36][C:37]([C:38]([F:39])([F:40])[F:41])=[O:42]>>[NH:8]1[CH2:9][CH2:10][CH:11]([O:14][c:15]2[cH:16][cH:17][c:18](-[n:21]3[n:22][c:23]([CH3:35])[cH:24][c:25]3[C:26]([NH:27][CH:28]3[CH2:29][CH2:30][CH2:31][CH2:32][CH2:33]3)=[O:34])[cH:19][cH:20]2)[CH2:12][CH2:13]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 589487744-[4-(5-Cyclohexylcarbamoyl-3-methylpyrazol-1-yl)phenoxy]piperidine-1-carboxylic acid tert-butyl ester

Product 1

HCID 589487705-Methyl-2-[4-(piperidin-4-yloxy)phenyl]-2H-pyrazole-3-carboxylic acid cyclohexylamide

Sources & evidence

ORD record
ord-00286bb26eee4e2dad1a664667ca5a73
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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