Lithium Hydroxide → 4-[[(3-Phenoxypropyl)thio]methyl]-1,3-oxathiolane-2,2-dipropanoic acid

HRID 1650238Notes

Reaction equation

HRID 1650238 reaction equation
[O:1]([CH2:8][CH2:9][CH2:10][S:11][CH2:12][CH:13]1[CH2:17][O:16][C:15]([CH2:25][CH2:26][C:27]([O:29]CC)=[O:28])([CH2:18][CH2:19][C:20]([O:22]CC)=[O:21])[S:14]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[Li+]>>[O:1]([CH2:8][CH2:9][CH2:10][S:11][CH2:12][CH:13]1[CH2:17][O:16][C:15]([CH2:18][CH2:19][C:20]([OH:22])=[O:21])([CH2:25][CH2:26][C:27]([OH:29])=[O:28])[S:14]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 3939Lithium HydroxideHCID 14405891Diethyl 4-[[(3-phenoxypropyl)thio]methyl]-1,3-oxathiolane-2,2-dipropanoate

Product 1

HCID 144058984-[[(3-Phenoxypropyl)thio]methyl]-1,3-oxathiolane-2,2-dipropanoic acid

Procedure

The title compound was prepared according to the procedure of Example 3 using the ester produced in Example 6 (2.44 g, 0.0052 mol) and aqueous lithium hydroxide solution (2 M, 9 ml). The product, 1.86 g (82%), was obtained as an oil.

Workup

  1. customThe product, 1.86 g (82%), was obtained as an oil

Sources & evidence

ORD record
ord-7580cebb00e64317a6e7b2fc6409a0c0
Source dataset
uspto-grants-1990_05
Patent number
US04923891

Reaction notes

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