2-Aminophenol → HCID 23437540, compound

HRID 1650344Notes

Reaction equation

HRID 1650344 reaction equation
C([C:3]1[CH:8]=[CH:7][C:6]([C:9]2[C:10]([NH:12][C:13](=[O:15])[CH:14]=2)=[O:11])=[CH:5][CH:4]=1)#C.NC1C=CC=CC=1[OH:23].C1(=O)OC(=O)C=C1.C(OC(=O)C)(=O)C>C([O-])(=O)C.[Ni+2].C([O-])(=O)C.C(N(CC)CC)C.CC(C)=O>[OH:23][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[C:10]([NH:12][C:13](=[O:15])[CH:14]=2)=[O:11])=[CH:5][CH:4]=1

Participants

8

Reactant 4

HCID 58012-AminophenolHCID 7918Acetic AnhydrideHCID 7923Maleic AnhydrideHCID 19853730HCID 19853730, compound

Product 1

HCID 23437540HCID 23437540, compound

Reagents, catalysts & solvents 3

HCID 9756Nickel AcetateCatalystHCID 180AcetoneSolventHCID 8471TriethylamineSolvent

Procedure

4-hydroxyphenyl maleimide was prepared by the same procedure as for 4-ethynylphenyl maleimide with the following starting materials aminophenol (54.5 g, 0.50 mole), maleic anhydride (49.0 g, 0.50 mole), acetone (500 ml), triethylamine (11 ml), nickel (II) acetate (0.5 g, 43 mmol), and acetic anhydride (63.8 g, 0.625 mol).

Sources & evidence

ORD record
ord-9af327c6dba24ff3894135c06966d48c
Source dataset
uspto-grants-1990_05
Patent number
US04923997

Reaction notes

Loading…