Sodium Iodide → HCID 19853684, compound

HRID 1650356Notes

Reaction equation

HRID 1650356 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8](=[O:11])[CH2:9]Cl.[Na+].[I-:13]>CC#N>[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8](=[O:11])[CH2:9][I:13]

Participants

4

Reactant 2

HCID 5238Sodium IodideHCID 124217441-(2-Aminophenyl)-2-chloroethan-1-one

Product 1

HCID 19853684HCID 19853684, compoundYield 90.5%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

To a solution of 33.11 g (195.21 mM) of 2'-amino-2-chloroacetophenone in 680 ml of CH3CN is added 87.8 g (585.63 mM) of NaI, and the mixture is stirred at room temperature for 45 minutes and concentrated under reduced pressure. The residue is dissolved in ethyl acetate, and the organic layer is washed with aqueous Na2S2O3, and brine in order, dried and concentrated to give 46.1 g (Yield: 90.5%) of 2'-amino-2-iodoacetophenone as crystals.

Workup

  1. concentrationconcentrated under reduced pressure
  2. dissolutionThe residue is dissolved in ethyl acetate
  3. washthe organic layer is washed with aqueous Na2S2O3, and brine in order
  4. customdried
  5. concentrationconcentrated

Sources & evidence

ORD record
ord-688d8d8add694ba5a82cc00ef891be8a
Source dataset
uspto-grants-1990_05
Patent number
US04923984

Reaction notes

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