Chloroacetic Acid → N-Phenylglycine

HRID 1650398Notes

Reaction equation

HRID 1650398 reaction equation
Cl[CH2:2][C:3]([OH:5])=[O:4].[NH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1>O>[C:7]1([NH:6][CH2:2][C:3]([OH:5])=[O:4])[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1

Participants

4

Reactant 2

HCID 300Chloroacetic AcidHCID 6115Aniline

Product 1

HCID 66025N-Phenylglycine

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

475 g (5 mols) of chloroacetic acid are heated at 100° C. with 930 g (10 mols) of aniline in 2 l. of water for 1.5 hours. After the mixture has been cooled, the N-phenylglycine formed is filtered off with suction and washed with water. Yield: 468 g (=62%, relative to the chloroacetic acid).

Workup

  1. temperatureAfter the mixture has been cooled

Sources & evidence

ORD record
ord-07c94b3e452e4a63aa7beb2bdf8725e7
Source dataset
uspto-grants-1990_05
Patent number
US04924004

Reaction notes

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