Hydrochloric Acid → HCID 131712503, 화합물

HRID 1650569노트

반응식

HRID 1650569 반응식
C([NH:3][C:4]1[S:5][CH:6]=[C:7]([C:9](=[N:26][O:27][CH2:28][C:29]#[CH:30])[C:10]([NH:12][CH:13]2[C:24](=[O:25])[N:15]3[C:16]([C:21]([OH:23])=[O:22])=[C:17]([Cl:20])[CH2:18][S:19][C@H:14]23)=[O:11])[N:8]=1)=O.Cl>CO>[NH2:3][C:4]1[S:5][CH:6]=[C:7]([C:9](=[N:26][O:27][CH2:28][C:29]#[CH:30])[C:10]([NH:12][CH:13]2[C:24](=[O:25])[N:15]3[C:16]([C:21]([OH:23])=[O:22])=[C:17]([Cl:20])[CH2:18][S:19][C@H:14]23)=[O:11])[N:8]=1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 1317125027-[2-(2-Formamidothiazol-4-yl)-2-propargyloxyiminoacetamido]-3-chloro-3-cephem-4-carboxylic acid

생성물 1

HCID 131712503HCID 131712503, 화합물수율 53.2%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A mixture of 7-[2-(2-formamidothiazol-4-yl)-2-propargyloxyiminoacetamido]-3-chloro-3-cephem-4-carboxylic acid (syn isomer, 1.4 g.), conc. hydrochloric acid (1.4 ml.) and methanol (20 ml.) was treated in a similar manner to that of Example 51-(2) to give 7-[2-(2-aminothiazol-4-yl)-2-propargyloxyiminoacetamido]-3-chloro-3-cephem-4-carboxylic acid (syn isomer, 0.7 g.), yellowish white powder.

후처리

  1. additionwas treated in a similar manner to that of Example 51-(2)

출처 및 근거

ORD 기록
ord-5bfde70cf2684cd3808fc9003783c4b2
출처 데이터셋
uspto-grants-1990_05
특허 번호
US04923998

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