HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1650601Generated: October 31, 2026
hydroxylamine-O-sulfonic acid → 4-Ethoxy-2,3-difluorobenzonitrile
https://huagongshe.com/reaction/1650601
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | hydroxylamine-O-sulfonic acid | HCID 76284 | — |
| Reactant | 4-Ethoxy-2,3-difluorobenzaldehyde | HCID 14495625 | — |
| Solvent | Water | HCID 962 | — |
| Product | 4-Ethoxy-2,3-difluorobenzonitrile | HCID 14495626 | — |
Reaction Steps
A mixture of 0.12 mole of hydroxylamine-0-sulfonic acid and 50 ml of water is added, at 30° C., to a mixture of 0.1 mole of 4-ethoxy-2,3-difluorobenzaldehyde and 100 ml of water, and the mixture is stirred for one hour. Warming to 65° C. for 2 hours and working up in the customary manner gives the nitrile in the form of a colourless solid, melting point 45° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04925590 |
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| Source dataset | uspto-grants-1990_05 |
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| ORD ID | ord-cabf4213c8a64933b9c2e22f5a35cbfb |
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| Source note | uspto-grants-1990_05 |
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