hydroxylamine-O-sulfonic acid → 4-Ethoxy-2,3-difluorobenzonitrile
Reaction equation
[NH2:1]OS(O)(=O)=O.[CH2:7]([O:9][C:10]1[CH:17]=[CH:16][C:13]([CH:14]=O)=[C:12]([F:18])[C:11]=1[F:19])[CH3:8]>O>[CH2:7]([O:9][C:10]1[CH:17]=[CH:16][C:13]([C:14]#[N:1])=[C:12]([F:18])[C:11]=1[F:19])[CH3:8]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 65 °C
Procedure
A mixture of 0.12 mole of hydroxylamine-0-sulfonic acid and 50 ml of water is added, at 30° C., to a mixture of 0.1 mole of 4-ethoxy-2,3-difluorobenzaldehyde and 100 ml of water, and the mixture is stirred for one hour. Warming to 65° C. for 2 hours and working up in the customary manner gives the nitrile in the form of a colourless solid, melting point 45° C.
Sources & evidence
- ORD record
- ord-cabf4213c8a64933b9c2e22f5a35cbfb
- Source dataset
- uspto-grants-1990_05
- Patent number
- US04925590
Reaction notes
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