Aluminum(III) Chloride → 2,3-Difluoro-4-hydroxybenzonitrile

HRID 1650602Notes

Reaction equation

HRID 1650602 reaction equation
C([O:3][C:4]1[CH:11]=[CH:10][C:7]([C:8]#[N:9])=[C:6]([F:12])[C:5]=1[F:13])C.[Cl-].[Al+3].[Cl-].[Cl-]>C1(C)C=CC=CC=1>[F:13][C:5]1[C:6]([F:12])=[C:7]([C:8]#[N:9])[CH:10]=[CH:11][C:4]=1[OH:3]

Participants

4

Reactant 2

HCID 6451240Aluminum(III) ChlorideHCID 144956264-Ethoxy-2,3-difluorobenzonitrile

Product 1

HCID 27369782,3-Difluoro-4-hydroxybenzonitrile

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A mixture of 0.1 mole of 4-ethoxy-2,3-difluorobenzonitrile, 0.12 mole of aluminium chloride and 150 ml of toluene is heated at the boil for 2 hours. Working up in the customary manner gives the phenol in the form of a colourless solid.

Workup

  1. temperatureis heated at the boil for 2 hours

Sources & evidence

ORD record
ord-20bbd3a5e7904b6f80e89768b5c955af
Source dataset
uspto-grants-1990_05
Patent number
US04925590

Reaction notes

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