Potassium Carbonate → HCID 14234966, compound

HRID 1650654Notes

Reaction equation

HRID 1650654 reaction equation
[CH2:1]([C:3]1[C:4]([O:18][CH3:19])=[N:5][C:6]2[N:7]([CH:10]=[C:11]([C:13]([O:15]CC)=[O:14])[N:12]=2)[C:8]=1[CH3:9])[CH3:2].C(=O)([O-])[O-].[K+].[K+]>CO.O>[CH2:1]([C:3]1[C:4]([O:18][CH3:19])=[N:5][C:6]2[N:7]([CH:10]=[C:11]([C:13]([OH:15])=[O:14])[N:12]=2)[C:8]=1[CH3:9])[CH3:2]

Participants

5

Reactant 2

HCID 11430Potassium CarbonateHCID 13304946HCID 13304946, compound

Product 1

HCID 14234966HCID 14234966, compoundYield 81,505.297%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

A mixture of 120 g (0.456 mmol) of ethyl 6-ethyl-7-methoxy-5-methylimidazo[1,2-a]pyrimidine-2-carboxylate and 120 g of potassium carbonate in 1200 ml of methanol and 600 ml of water was heated at reflux for 2 hours and the methanol was then evaporated. 150 ml of more water were added, and the resulting solution was acidified to a pH of 1 with concentrated HCl. The solid obtained was filtered and was washed with water, then dried under vacuum over P2O5 at 80° C. to obtain 87.43 g (82% yield) of 6-ethyl-7-methoxy-5-methylimidazo[1,2-a]pyrimidine-2-carboxylic acid.

Workup

  1. temperaturewas heated
  2. temperatureat reflux for 2 hours
  3. customthe methanol was then evaporated
  4. addition150 ml of more water were added
  5. customThe solid obtained
  6. filtrationwas filtered
  7. washwas washed with water
  8. dry with materialdried under vacuum over P2O5 at 80° C.

Sources & evidence

ORD record
ord-12ad521b664a4ae48e673a4664e16f63
Source dataset
uspto-grants-1990_05
Patent number
US04925846

Reaction notes

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