Potassium Hydroxide → HCID 14577394, compound

HRID 1650658Notes

Reaction equation

HRID 1650658 reaction equation
[OH-].[K+].CC1C=C(C=CC=1)C([O:9][CH2:10][CH:11]1[CH2:16][CH2:15][N:14]([C:17](=[O:25])[C:18]2[CH:23]=[CH:22][CH:21]=[C:20]([CH3:24])[CH:19]=2)[CH2:13][CH2:12]1)=O>C(O)C.O>[CH3:24][C:20]1[CH:19]=[C:18]([CH:23]=[CH:22][CH:21]=1)[C:17]([N:14]1[CH2:15][CH2:16][CH:11]([CH2:10][OH:9])[CH2:12][CH2:13]1)=[O:25]

Participants

5

Reactant 2

HCID 14797Potassium HydroxideHCID 14577393HCID 14577393, compound

Product 1

HCID 14577394HCID 14577394, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolvent2×HCID 962WaterSolvent

Procedure

A solution of 12.76 g (0.23 mole) of potassium hydroxide in 75 ml of ethanol and 75 ml of water is added to a solution of 80 g (0.23 mole) of [1-(3-methylbenzoyl)-4-piperidinyl]methyl 3-methylbenzoate in 400 ml of ethanol. The mixture is stirred at 20° C. for 3h, the solvent evaporated under reduced pressure and the aqueous phase is extracted with ethyl acetate. The organic phase is washed with water then with a saturated aqueous solution of sodium chloride, and dried over magnesium sulphate. The solvent is evaporated under reduced pressure and 53 g of an alcohol are obtained, which is used just as it is in the next stage.

Workup

  1. customthe solvent evaporated under reduced pressure
  2. extractionthe aqueous phase is extracted with ethyl acetate
  3. washThe organic phase is washed with water
  4. dry with materialwith a saturated aqueous solution of sodium chloride, and dried over magnesium sulphate
  5. customThe solvent is evaporated under reduced pressure and 53 g of an alcohol
  6. customare obtained

Sources & evidence

ORD record
ord-7447162e954c439598bcd6975c3972a1
Source dataset
uspto-grants-1990_05
Patent number
US04925850

Reaction notes

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