Potassium Hydroxide → HCID 14577394, compound

Participants

Reaction Steps

A solution of 12.76 g (0.23 mole) of potassium hydroxide in 75 ml of ethanol and 75 ml of water is added to a solution of 80 g (0.23 mole) of [1-(3-methylbenzoyl)-4-piperidinyl]methyl 3-methylbenzoate in 400 ml of ethanol. The mixture is stirred at 20° C. for 3h, the solvent evaporated under reduced pressure and the aqueous phase is extracted with ethyl acetate. The organic phase is washed with water then with a saturated aqueous solution of sodium chloride, and dried over magnesium sulphate. The solvent is evaporated under reduced pressure and 53 g of an alcohol are obtained, which is used just as it is in the next stage.

Provenance & Evidence