Isobutyrophenone → HCID 23052300, compound

HRID 1650673Notes

Reaction equation

HRID 1650673 reaction equation
Cl.[NH:2]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[CH2:11][CH2:12][C:13](=[O:16])[NH:14][N:15]=2)=[CH:6][CH:5]=1)N.[CH3:17][CH:18]([CH3:27])[C:19]([C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)=O>C(O)(=O)C>[C:21]1([C:19]2[C:18]([CH3:27])([CH3:17])[C:9]3[C:4](=[CH:5][CH:6]=[C:7]([C:10]4[CH2:11][CH2:12][C:13](=[O:16])[NH:14][N:15]=4)[CH:8]=3)[N:2]=2)[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1

Participants

4

Reactant 2

HCID 69144IsobutyrophenoneHCID 19780113HCID 19780113, compound

Product 1

HCID 23052300HCID 23052300, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

3 g. (12.5 mMole) 6-(4-hydrazinophenyl)-2,3,4,5-tetrahydropyridazin-3-one hydrochloride, 2.4 g. (16.2 mMole) α-methylpropiophenone and 40 ml. glacial acetic acid were stirred for 8 hours at 100° C. under an atmosphere of nitrogen. The glacial acetic acid was subsequently distilled off and the residue suspended in water, neutralised and filtered with suction. After recrystallisation from ethanol, there was obtained 1.6 g. (40% of theory) of the title compound; m.p. 200°-201° C.

Workup

  1. distillationThe glacial acetic acid was subsequently distilled off
  2. filtrationneutralised and filtered with suction
  3. customAfter recrystallisation from ethanol
  4. customthere was obtained 1.6 g

Sources & evidence

ORD record
ord-dacdfdc6a74a4b2b99a0bb1e5a5aa2b4
Source dataset
uspto-grants-1990_05
Patent number
US04925845

Reaction notes

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