HCID 23052320, compound → HCID 23052289, compound

HRID 1650674Notes

Reaction equation

HRID 1650674 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([C:7]2[C:15]([CH3:17])([CH3:16])[C:14]3[C:9](=[CH:10][CH:11]=[C:12]([C:18]4[CH2:19][CH2:20][C:21](=[O:24])[NH:22][N:23]=4)[CH:13]=3)[N:8]=2)=[CH:3][CH:2]=1>[O-2].[O-2].[Mn+4].O1CCOCC1>[N:1]1[CH:6]=[CH:5][C:4]([C:7]2[C:15]([CH3:16])([CH3:17])[C:14]3[C:9](=[CH:10][CH:11]=[C:12]([C:18]4[CH:19]=[CH:20][C:21](=[O:24])[NH:22][N:23]=4)[CH:13]=3)[N:8]=2)=[CH:3][CH:2]=1

Participants

4

Reactant 1

HCID 23052320HCID 23052320, compound

Product 1

HCID 23052289HCID 23052289, compound

Reagents, catalysts & solvents 2

HCID 178418406HCID 178418406, compoundCatalystHCID 312751,4-DioxaneSolvent

Procedure

1.75 g. (5.5 mMole) 2-(4-pyridyl)-3,3-dimethyl-5-(3-oxo-2,3,4,5-tetrahydro-6-pyridazinyl)-3H-indole (see Example 2 b)) was stirred with 25 g. manganese dioxide in 260 ml. dioxan for 20 hours at 90° C. The reaction mixture was subsequently filtered off with suction, the residue stirred up with methanol/methylene chloride and the combined filtrates evaporated to dryness. After crystallisation from methanol, there was obtained 1 g. (58% of theory) of the title compound; m.p. 305°-307° C.

Workup

  1. filtrationThe reaction mixture was subsequently filtered off with suction
  2. customthe combined filtrates evaporated to dryness
  3. customAfter crystallisation from methanol
  4. customthere was obtained 1 g

Sources & evidence

ORD record
ord-cb5dc66aecf14e04806a84d7bc841799
Source dataset
uspto-grants-1990_05
Patent number
US04925845

Reaction notes

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