反应详情

温度

100 °C

2-(2-(3-Cyanophenyl)ethenyl)-4-isopropylthiazole prepared in Synthetic Example (2.54 g, 10.0 mmol) was dissolved in a mixed solvent of acetic acid (5 ml) and concentrated hydrochloric acid (10 ml) and the resulting mixture was heated under stirring at 100° C. for 4 hours. After water was added, the reaction mixture was extracted with ethyl acetate and dried. The solvent was distilled out to afford the indicated compound (2.51 g) with a yield of 92%.

1. temperaturethe resulting mixture was heated
2. extractionthe reaction mixture was extracted with ethyl acetate
3. customdried
4. distillationThe solvent was distilled out