HCID 178418361, compound → HCID 178460534, compound

HRID 1650691Notes

Reaction equation

HRID 1650691 reaction equation
[C:1]([CH:4]([N:6]1[CH2:11][CH2:10][CH:9]=[C:8]([C:12]2[NH:16][N:15]=[N:14][N:13]=2)[CH2:7]1)[CH3:5])([OH:3])=[O:2].[H][H]>C(OCC)(=O)C.[Pd]>[C:1]([CH:4]([N:6]1[CH2:11][CH2:10][CH2:9][CH:8]([C:12]2[NH:16][N:15]=[N:14][N:13]=2)[CH2:7]1)[CH3:5])([OH:3])=[O:2]

Participants

5

Reactant 2

HCID 178418361HCID 178418361, compoundHCID 178460533HCID 178460533, compound

Product 1

HCID 178460534HCID 178460534, compoundYield 80%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

To a solution of 5 (14.9 g, 0.078 mol) in ethyl acetate (160 ml) acetic acid (25 ml) and 5% palladium on charcoal (1.25 g) were added. The mixture was shaken for 24 hours with 3.5 atm. of hydrogen pressure. The mixture was filtered and evaporated to yield the title compound as an oil (12.07 g, 80%).

Workup

  1. filtrationThe mixture was filtered
  2. customevaporated

Sources & evidence

ORD record
ord-94801359b00c4b93a0a3db8ba4341ff7
Source dataset
uspto-grants-1990_05
Patent number
US04925858

Reaction notes

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