2-Aminothiazole → HCID 178522555, compound

HRID 1650713Notes

Reaction equation

[NH2:1][C:2]1[S:3][CH:4]=[CH:5][N:6]=1.[OH:7][C:8]1[C:13]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[C:12]([C:20]2[S:21][CH:22]=[CH:23][CH:24]=2)[N:11]=[C:10]([C:25]([F:28])([F:27])[F:26])[C:9]=1[C:29](OCC)=[O:30]>>[OH:7][C:8]1[C:13]([C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=2)=[C:12]([C:20]2[S:21][CH:22]=[CH:23][CH:24]=2)[N:11]=[C:10]([C:25]([F:28])([F:27])[F:26])[C:9]=1[C:29]([NH:1][C:2]1[S:3][CH:4]=[CH:5][N:6]=1)=[O:30]

Participants

Reactant 2

HCID 21552-Aminothiazole

HCID 178469140HCID 178469140, compound

Product 1

HCID 178522555HCID 178522555, compoundYield 73.9%

Procedure

Using the procedure of Example 5, 10 g of amino thiazol and 6.9 g of the product of Step D were reacted to obtain 5.8 g of the expected product which was crystallized from acetonitrile melting at 260°-262° C.

Workup

customwere reacted

Sources & evidence

ORD record: ord-62cc5078f2a1431dbd56620360b8a0bb
Source dataset: uspto-grants-1990_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04925859

Reaction notes

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