Sodium Bisulfite → HCID 86743919, compound

HRID 1650714Notes

Reaction equation

HRID 1650714 reaction equation
[F:1][C:2]([F:21])([F:20])[C:3]([NH:5][C:6](=[C:8]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[C:9]([O:11]CC)=[O:10])[CH3:7])=[O:4].S(=O)(O)[O-].[Na+]>[I-].C[SiH](C)C>[F:1][C:2]([F:20])([F:21])[C:3]([NH:5][C:6](=[C:8]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[C:9]([OH:11])=[O:10])[CH3:7])=[O:4]

Participants

4

Reactant 2

HCID 23665763Sodium BisulfiteHCID 86743920HCID 86743920, compound

Product 1

HCID 86743919HCID 86743919, compoundYield 78.2%

Reagents, catalysts & solvents 1

HCID 131716375HCID 131716375, compoundSolvent

Procedure

16.5 g of the product of Step A were dissolved in 15.6 ml of trimethylsilane iodide and after 16 hours of reflux, the solution was poured into 200 ml of a solution of sodium bisulfite and then was extracted with ether. The extracts were washed with water, dried and concentrated to dryness under reduced pressure to obtain 11.7 g of the expected product which after crystallization from heptane melted at 174° C.

Workup

  1. temperatureof reflux
  2. extractionwas extracted with ether
  3. washThe extracts were washed with water
  4. customdried
  5. concentrationconcentrated to dryness under reduced pressure

Sources & evidence

ORD record
ord-88f4637002f640e89683bd16dfe98e93
Source dataset
uspto-grants-1990_05
Patent number
US04925859

Reaction notes

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