2-Aminothiazole → HCID 178432832, compound

HRID 1650716Notes

Reaction equation

HRID 1650716 reaction equation
[NH2:1][C:2]1[S:3][CH:4]=[CH:5][N:6]=1.[OH:7][C:8]1[C:13]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[C:12]([CH3:20])[N:11]=[C:10]([C:21]([F:24])([F:23])[F:22])[C:9]=1[C:25](OCC)=[O:26]>>[OH:7][C:8]1[C:13]([C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=2)=[C:12]([CH3:20])[N:11]=[C:10]([C:21]([F:24])([F:22])[F:23])[C:9]=1[C:25]([NH:1][C:2]1[S:3][CH:4]=[CH:5][N:6]=1)=[O:26]

Participants

3

Reactant 2

HCID 21552-AminothiazoleHCID 178469141HCID 178469141, compound

Product 1

HCID 178432832HCID 178432832, compoundYield 79.3%

Procedure

Using the procedure of Example 5, 6.25 g of 2-aminothiazole and 4 g of the product of Step F were reacted to obtain 3.7 g of the expected product melting greater than 260° C. after crystallizing from acetonitrile.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-c590979abcc1452081481fd860699a35
Source dataset
uspto-grants-1990_05
Patent number
US04925859

Reaction notes

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