2-Aminothiazole → HCID 178459021, compound

HRID 1650719Notes

Reaction equation

[C:1]1([C:7]2[C:8]([OH:29])=[C:9]([C:24]([O:26]CC)=O)[C:10]([CH:19]([O:22][CH3:23])[CH2:20][CH3:21])=[N:11][C:12]=2[C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH2:30][C:31]1[S:32][CH:33]=[CH:34][N:35]=1>>[C:1]1([C:7]2[C:8]([OH:29])=[C:9]([C:24]([NH:30][C:31]3[S:32][CH:33]=[CH:34][N:35]=3)=[O:26])[C:10]([CH:19]([O:22][CH3:23])[CH2:20][CH3:21])=[N:11][C:12]=2[C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

Reactant 2

HCID 21552-Aminothiazole

HCID 178468937HCID 178468937, compound

Product 1

HCID 178459021HCID 178459021, compoundYield 81.7%

Procedure

Using the procedure of Example 5, 9.3 g of the product of Step E and 12 g of 2-aminothiazole were reacted to obtain 8.65 g of the expected product which after crystallization from ether melted at 236° to 238° C.

Workup

customwere reacted

Sources & evidence

ORD record: ord-05ba66c46cd74f20b8e0903968fc7c62
Source dataset: uspto-grants-1990_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04925859

Reaction notes

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