Acetone → HCID 15158052, compound

HRID 1650724Notes

Reaction equation

HRID 1650724 reaction equation
CC(=O)C.O.[NH2:6][NH2:7].C(O[CH:11](OCC)[CH:12]([C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][N:22]=1)[C:13]([C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][N:16]=1)=O)C>C(O)C>[N:22]1[CH:23]=[CH:24][CH:25]=[CH:26][C:21]=1[C:12]1[CH:11]=[N:6][NH:7][C:13]=1[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][N:16]=1

Participants

5

Reactant 3

HCID 180AcetoneHCID 24654Hydrazine hydrate (1:1)HCID 15158051HCID 15158051, compound

Product 1

HCID 15158052HCID 15158052, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The propanone was dissolved in 1 L of ethanol, 5.8 mL (0.12 mol) of hydrazine hydrate was added, and the mixture was heated to reflux for 1 hr. The ethanol was stripped off in vacuo, and the residue was put through a 600 g silica gel column eluting with 1:1 hexane-acetone to yield about 4 g of 4,5-bis(2-pyridinyl)-1H-pyrazole as a light tan solid after removal of solvent.

Workup

  1. temperaturethe mixture was heated
  2. temperatureto reflux for 1 hr
  3. washeluting with 1:1 hexane-acetone

Sources & evidence

ORD record
ord-e63e795d09e14f0d889667c665dfdc1b
Source dataset
uspto-grants-1990_05
Patent number
US04925857

Reaction notes

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