Hydrogen Bromide → HCID 67792003, compound

HRID 1650754Notes

Reaction equation

HRID 1650754 reaction equation
[C:1]1([C:7]2[C:15]([CH:16]=[CH:17][C:18]([N:20]3[CH2:25][CH2:24][CH2:23][CH2:22][C@@H:21]3[CH2:26][CH3:27])=[O:19])=[C:10]3[CH:11]=[CH:12][CH:13]=[CH:14][N:9]3[N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[BrH:28]>>[BrH:28].[C:1]1([C:7]2[C:15]([CH:16]=[CH:17][C:18]([N:20]3[CH2:25][CH2:24][CH2:23][CH2:22][C@@H:21]3[CH2:26][CH3:27])=[O:19])=[C:10]3[CH:11]=[CH:12][CH:13]=[CH:14][N:9]3[N:8]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

3

Reactant 2

HCID 260Hydrogen BromideHCID 57088708HCID 57088708, compound

Product 1

HCID 67792003HCID 67792003, compound

Procedure

(2S)-1-[3-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)acryloyl]-2-ethylpiperidine (trans isomer)(2.11 g) was converted to hydrobromic acid salt in a usual manner. The crystals were recrystallized from a mixture of ethyl acetate and acetone to give yellow crystals of (2S)-1-[3-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)acryloyl]-2-ethylpiperidine.hydrobromide (trans isomer)(1.75 g).

Workup

  1. customThe crystals were recrystallized from a mixture of ethyl acetate and acetone

Sources & evidence

ORD record
ord-fd696d3625b5420f85ef6fed5e3260cd
Source dataset
uspto-grants-1990_05
Patent number
US04925849

Reaction notes

Loading…