Triethylamine → 5-(N,N-diethylamino)-3-(tert-butyl)-1-(2-nitro-4-trifluoromethylphenyl)-1H-1,2,4-triazole

HRID 1650764Notes

Reaction equation

HRID 1650764 reaction equation
[N+:1]([C:4]1[CH:9]=[C:8]([C:10]([F:13])([F:12])[F:11])[CH:7]=[CH:6][C:5]=1[NH:14][N:15]=[C:16](Br)[C:17]([CH3:20])([CH3:19])[CH3:18])([O-:3])=[O:2].[CH2:22]([N:24]([CH2:27][CH3:28])[C:25]#[N:26])[CH3:23].C(N(CC)CC)C>C1(C)C=CC=CC=1>[CH2:22]([N:24]([C:25]1[N:14]([C:5]2[CH:6]=[CH:7][C:8]([C:10]([F:13])([F:12])[F:11])=[CH:9][C:4]=2[N+:1]([O-:3])=[O:2])[N:15]=[C:16]([C:17]([CH3:20])([CH3:19])[CH3:18])[N:26]=1)[CH2:27][CH3:28])[CH3:23]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 12050DiethylcyanamideHCID 86743922HCID 86743922, compound

Product 1

HCID 146243415-(N,N-diethylamino)-3-(tert-butyl)-1-(2-nitro-4-trifluoromethylphenyl)-1H-1,2,4-triazoleYield 84.4%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent2×

Procedure

7.4 g (0.02 mol) of 2,2-dimethylpropionyl bromide 2-nitro-4-trifluoromethylphenylhydrazone and 2.0 g (0.02 mol) of N,N-diethylcyanamide were added to 100 ml of toluene. Then, 2.2 g (0.022 mol) of triethylamine was dropwise added under stirring at room temperature. After completion of the dropwise addition, stirring was continued at room temperature for further 1 hour. Then, 100 ml of toluene was added and washed with water. The organic layer was dried, and the solvent was distilled off. The residue was purified by silica gel column chromatography to obtain 6.5 g (yield: 84.4%) of the desired compound as a pale yellow liquid. Refractive index nD20 : 1.4911.

Workup

  1. additionAfter completion of the dropwise addition
  2. stirringstirring
  3. washwashed with water
  4. customThe organic layer was dried
  5. distillationthe solvent was distilled off
  6. customThe residue was purified by silica gel column chromatography

Sources & evidence

ORD record
ord-4eb6eb4f9ae149d9bf2610c10b131d30
Source dataset
uspto-grants-1990_05
Patent number
US04925864

Reaction notes

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