Ammonia → HCID 178458348, compound

HRID 1650797Notes

Reaction equation

HRID 1650797 reaction equation
C[O:2][C:3]([CH:5]([O:8][C:9]1[CH:21]=[CH:20][C:12]([CH:13]=[CH:14][C:15]2[N:19]=[CH:18][NH:17][N:16]=2)=[CH:11][CH:10]=1)[CH2:6][CH3:7])=O.[NH3:22].C(O)C>CC(C)=O>[C:3]([CH:5]([O:8][C:9]1[CH:21]=[CH:20][C:12]([CH:13]=[CH:14][C:15]2[N:19]=[CH:18][NH:17][N:16]=2)=[CH:11][CH:10]=1)[CH2:6][CH3:7])(=[O:2])[NH2:22]

Participants

5

Reactant 3

HCID 222Ammonia2×HCID 702EthanolHCID 178458349HCID 178458349, compound

Product 1

HCID 178458348HCID 178458348, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

3-[4-(1-methoxycarbonylpropoxy)styryl]-1,2,4-triazole (0.5 g--prepared as the intermediate for Example 22 above), concentrated ammonia (5 ml) and ethanol (10 ml) were placed in a Carius tube, and further saturated with gaseous ammonia for 20 minutes. The tube was cooled in acetone/solid carbon dioxide and sealed, and then heated at 110° for 24 hours. The tube was cooled and opened, and the contents were evaporated to dryness to give the required 3-[4-(1-carbamoylpropoxy)styryl]-1,2,4-triazole, crystallised from methanol, softened at 50° and mp~150°.

Workup

  1. customsealed
  2. temperatureheated at 110° for 24 hours
  3. temperatureThe tube was cooled
  4. customthe contents were evaporated to dryness

Sources & evidence

ORD record
ord-cfc09c69e38b4e4ea8a5ba9bd7fa6b49
Source dataset
uspto-grants-1990_05
Patent number
US04925863

Reaction notes

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