Ammonia → HCID 178458348, compound

Participants

Reaction Steps

3-[4-(1-methoxycarbonylpropoxy)styryl]-1,2,4-triazole (0.5 g--prepared as the intermediate for Example 22 above), concentrated ammonia (5 ml) and ethanol (10 ml) were placed in a Carius tube, and further saturated with gaseous ammonia for 20 minutes. The tube was cooled in acetone/solid carbon dioxide and sealed, and then heated at 110° for 24 hours. The tube was cooled and opened, and the contents were evaporated to dryness to give the required 3-[4-(1-carbamoylpropoxy)styryl]-1,2,4-triazole, crystallised from methanol, softened at 50° and mp~150°.

Provenance & Evidence