Hydrochloric Acid → HCID 14276107, compound

HRID 1650802Notes

Reaction equation

HRID 1650802 reaction equation
[CH2:1]1[O:9][C:8]2[C:3](=[C:4]([C:16]3[C:21]([C:22]([O:24]C)=[O:23])=[CH:20][C:19]([O:26][CH3:27])=[C:18]([O:28][CH3:29])[C:17]=3[O:30][CH3:31])[C:5]([C:12]([O:14]C)=[O:13])=[CH:6][C:7]=2[O:10][CH3:11])[O:2]1.[OH-].[K+].Cl>O1CCOCC1>[CH2:1]1[O:9][C:8]2[C:3](=[C:4]([C:16]3[C:21]([C:22]([OH:24])=[O:23])=[CH:20][C:19]([O:26][CH3:27])=[C:18]([O:28][CH3:29])[C:17]=3[O:30][CH3:31])[C:5]([C:12]([OH:14])=[O:13])=[CH:6][C:7]=2[O:10][CH3:11])[O:2]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 14099682HCID 14099682, compound

Product 1

HCID 14276107HCID 14276107, compoundYield 92.1%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Conditions

Temperature
70 °C

Procedure

In 50 ml of dioxane was dissolved 1.3 g of dimethyl 2',3'-methylenedioxy-2,3,4,4'-tetramethoxy-1,1'-biphenyl-6,6'-dicarboxylate obtained in Example 2, and 10 mg of potassium hydroxide was added to the solution. The mixture was heated at 70° C. and stirred overnight. When the pH value of the mixture was adjusted to 1 by 3N hydrochloric acid, crystals were precipitated. The precipitated crystals were recovered by filtration and recrystallized from ethanol to obtain 1.12 g of 2',3'-methylenedioxy-2,3,4,4'-tetramethoxy-1,1'-biphenyl-6,6'-dicarboxylic acid having the following physical properties (the yield was 92%).

Workup

  1. additionwas added to the solution
  2. customwere precipitated
  3. filtrationThe precipitated crystals were recovered by filtration
  4. customrecrystallized from ethanol

Sources & evidence

ORD record
ord-6a049748b0494e4aad2eaa9c78de8ea5
Source dataset
uspto-grants-1990_05
Patent number
US04925872

Reaction notes

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