Hydrochloric Acid → HCID 14515527, compound

HRID 1650804Notes

Reaction equation

HRID 1650804 reaction equation
C[C:2]1[C:3]([O:33][CH3:34])=[C:4]([O:31][CH3:32])[C:5]([O:28][CH2:29][CH3:30])=[C:6]([C:14]2[C:19]([C:20]([O-:22])=[O:21])=[CH:18][C:17]([O:23][CH3:24])=[C:16]3[O:25][CH2:26][O:27][C:15]=23)[C:7]=1[C:8]([O:10]CCC)=[O:9].[OH-].[K+].Cl>O1CCOCC1>[CH2:29]([O:28][C:5]1[C:4]([O:31][CH3:32])=[C:3]([O:33][CH3:34])[CH:2]=[C:7]([C:8]([OH:10])=[O:9])[C:6]=1[C:14]1[C:19]([C:20]([OH:22])=[O:21])=[CH:18][C:17]([O:23][CH3:24])=[C:16]2[O:25][CH2:26][O:27][C:15]=12)[CH3:30]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 131716376HCID 131716376, compound

Product 1

HCID 14515527HCID 14515527, compoundYield 86%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Conditions

Temperature
70 °C

Procedure

In 4 ml of dioxane was dissolved 48 mg of methyl -ethoxy-2',3'-methylenedioxy-6-propoxycarbonyl-3,4,4'-trimethoxy-1,1'-biphenyl-6'-carboxylate obtained in Example 9, and 1 ml of a 5% aqueous solution of potassium hydroxide was added to the solution. The mixture was heated at 70° C. and stirred overnight, the pH value was adjusted to 1 by 3N hydrochloric acid, and the mixture was extracted with chloroform. The solvent was removed from the extract to obtain 36 mg of 2-ethoxy-2',3'-methylenedioxy-3,4,4'-trimethoxy-1,1'-biphenyl-6,6'-dicarboxylic acid having the following physical properties (the yield was 86%).

Workup

  1. additionwas added to the solution
  2. extractionthe mixture was extracted with chloroform
  3. customThe solvent was removed from the
  4. extractionextract

Sources & evidence

ORD record
ord-daf682504cfc46049b19389c444c844f
Source dataset
uspto-grants-1990_05
Patent number
US04925872

Reaction notes

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