反应详情

A mixture of (2S,4R)-4-methanesulfonyloxy-1-(4-nitrobenzyloxycarbonyl)-2-(2-oxoimidazolidin-1-yl)carbonylpyrrolidine (30 g), 10% palladium on carbon (10 g), methanol (300 ml) and tetrahydrofuran (150 ml) was stirred for 5 hours under atmospheric pressure of hydrogen at ambient temperature. After the catalyst was filtered off, the filtrate was evaporated in vacuo to give a residue. The residue was chromatographed on silica gel (250 g) eluting with a mixture of chloroform and methanol (9:1 V/V). The fractions containing the desired compound were collected and evaporated in vacuo to give (2S,4R)-4-methanesulfonyloxy-2-(2-oxoimidazolidin-1-yl)carbonylpyrrolidine (14.92 g).

1. filtrationAfter the catalyst was filtered off
2. customthe filtrate was evaporated in vacuo
3. customto give a residue
4. customThe residue was chromatographed on silica gel (250 g)
5. washeluting with a mixture of chloroform and methanol (9:1 V/V)
6. additionThe fractions containing the desired compound
7. customwere collected
8. customevaporated in vacuo